Unraveling of genetic causes of atrial fibrillation: from mechanism to treatment

Unraveling of genetic causes of atrial fibrillation: from mechanism to treatment
Written by:Prof. Dr. Bianca Brundel ,

Younger people may experience atrial fibrillation due to a genetic cause. The German-Dutch research team has identified atrial fibrillation families that carry mutations in genes responsible for proteins of the cytoskeleton, the building blocks of heart cells.

 

Recently published findings from the lab of Prof. Bianca Brundel indicate that atrial fibrillation causes DNA damage in atrial cells. In addition, cytoskeletal protein mutations are also found to cause DNA damage in the atrial cells and thus may drive atrial fibrillation. The project aims to

  • uncover the exact mechanism by which mutations in cytoskeletal proteins cause DNA damage and atrial fibrillation.
  • test several drugs to develop new therapies for genetic atrial fibrillation patients.

Project name: DnAFiX – DNA damage in cytoskeletal protein mutation-induced atrial fibrillation: a guide to novel treatment and screening targets | Partners: Prof. Bianca Brundel, (Amsterdam UMC); Prof. Natasja de Groot (Erasmus MC); Prof. Rudolf de Boer (UMCG, Groningen), Prof. Niels Voigt (UMCG, Göttingen), Prof. Denise Hilfiker-Kleiner (University Hannover), Prof. Hendrik Milting (HDZ, Bad-Oeyenhausen)

 

This project has been awarded within the British, Dutch, and German initiative to enable scientists to collaborate on joint projects to investigate essential issues in cardiovascular medicine. The organisations British Heart Foundation (BHF), Hartstichting, and the German Centre for Cardiovascular Research (DZHK) have set up a joint research programme for this purpose. DnAFix project is one out of three awarded projects. https://dzhk.de/en/news/latest-news/article/working-together-to-strengthen-cardiovascular-research-in-europe/

 

For further information on this project you can contact Prof. Bianca Brundel, b.brundel@amsterdamumc.nl

 

Thank you Miles Henderson for preparing the graphic abstract.

Do you know someone who might be interested in this?

Related articles

Atrial Fibrillation Finger Printing

Atrial Fibrillation Finger Printing
Written by: Prof. Dr. Bianca Brundel , ,

On the 18th of April 2020, the international journal Clinical Cardiology has published our manuscript ‘Atrial Fibrillation Fingerprinting; Spotting Bio-Electrical Markers to Early Recognize Atrial Fibrillation by the Use of

Inflammasomes and Proteostasis: Novel Molecular Mechanisms Associated With Atrial Fibrillation

Inflammasomes and Proteostasis: Novel Molecular Mechanisms Associated With Atrial Fibrillation
Written by: Prof. Dr. Bianca Brundel ,

Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia, affects millions of people worldwide. AF is associated with common risk factors, including hypertension, diabetes mellitus, and obesity, and

Miles Henderson describes PPG technology to detect atrial fibrillation

Weighing the Effectiveness of Photoplethysmography Signal Analysis in Population Diagnosis of Atrial Fibrillation

Weighing the Effectiveness of Photoplethysmography Signal Analysis in Population Diagnosis of Atrial Fibrillation
Written by: Prof. Dr. Bianca Brundel ,

Review paper by Miles Henderson, biomedical student at the Amsterdam University College. Photoplethysmography has become an accessible component of smartwatches in recent years. The primary advantage of these devices is

Leave a Reply