Prof. Dr. Bianca Brundel

Moleculair en celbioloog bij VUMC Amsterdam https://orcid.org/0000-0002-4768-234X
Bianca Brundel studeerde moleculaire en cellulaire biologie aan de Vrije Universiteit Amsterdam, waarna ze promotie onderzoek naar DNA, RNA en structuur veranderingen in patiënten met boezemfibrilleren verrichtte aan het UMCG. Sinds 2016 is zij professor bij de afdeling Fysiologie Amsterdam UMC, locatie VUmc, waar zij zich bezighoudt met het ontrafelen van de moleculaire oorzaken van boezemfibrilleren. Voor dit onderzoek heeft zij unieke dierproefvrije modellen voor boezemfibrilleren ontwikkeld: gekweekte boezem hartcellen en fruitvliegen. Door gebruik te maken van deze modellen heeft zij nieuwe aangrijpingspunten voor geneesmiddelen en diagnostiek ontdekt. Om deze bevindingen naar de patiënten te brengen werkt zij samen met Prof. Natasja de Groot (Erasmus MC) en de stichting AFIP. Haar ontdekkingen zijn recent gepubliceerd in toonaangevende wetenschappelijke tijdschriften waaronder Nature Communications, Nature Reviews Cardiology, Circulation en Circulation Research.

Opleidingen van Prof. Dr. Bianca Brundel

Artikelen van Prof. Dr. Bianca Brundel

DNA damage as a new biomarker for Atrial Fibrillation

DNA damage as a new biomarker for Atrial Fibrillation
Written by: Prof. Dr. Bianca Brundel , ,

Last year, AFIP published an article on the discovery made by the team of Prof. Bianca Brundel (Amsterdam UMC), that atrial fibrillation (AF) is associated with DNA damage in the

L-glutamine alters HSP levels and normalises energy status in patients with atrial fibrillation

L-glutamine alters HSP levels and normalises energy status in patients with atrial fibrillation
Written by: Prof. Dr. Bianca Brundel , ,

Treatment strategies for atrial fibrillation (AF) are only moderately effective and do not prevent AF onset and progression. This difficulty of treatment predicts a great need to dissect root causes

Unraveling of genetic causes of atrial fibrillation: from mechanism to treatment

Unraveling of genetic causes of atrial fibrillation: from mechanism to treatment
Written by: Prof. Dr. Bianca Brundel ,

Younger people may experience atrial fibrillation due to a genetic cause. The German-Dutch research team has identified atrial fibrillation families that carry mutations in genes responsible for proteins of the

Inflammasomes and Proteostasis: Novel Molecular Mechanisms Associated With Atrial Fibrillation

Inflammasomes and Proteostasis: Novel Molecular Mechanisms Associated With Atrial Fibrillation
Written by: Prof. Dr. Bianca Brundel ,

Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia, affects millions of people worldwide. AF is associated with common risk factors, including hypertension, diabetes mellitus, and obesity, and

Weighing the Effectiveness of Photoplethysmography Signal Analysis in Population Diagnosis of Atrial Fibrillation

Weighing the Effectiveness of Photoplethysmography Signal Analysis in Population Diagnosis of Atrial Fibrillation
Written by: Prof. Dr. Bianca Brundel ,

Review paper by Miles Henderson, biomedical student at the Amsterdam University College. Photoplethysmography has become an accessible component of smartwatches in recent years. The primary advantage of these devices is