Heat Shock Proteins Protect Against Atrial Fibrillation in Experimental Models

For 15 year we have been aware of the fact that substances that increase the so-called Heat Shock Proteins (HSP) in the atrium, can protect the heart against atrial fibrillation. A patient with atrial fibrillation then found an article in the scientific literature stating that L-glutamine helps make these protective HSPs. This was the first step towards successful collaborative research.

Input from this patient enabled us to conduct a clinical study on the effect of L-glutamine in patients with atrial fibrillation. We found that L-glutamine has a clear effect on HSP levels in the blood, and therefore these effects are associated with more energy in the body.

What is currently known about L-Glutamine and atrial fibrillation so far?

  • L-glutamine is a common amino acid in the body and is a building block for many other amino acids and proteins.
  • L-glutamine helps build muscle and is therefore widely used by bodybuilders.
  • L-glutamine is safe in healthy people, but can cause side effects in people with kidney problems due to diabetes.
  • L-glutamine provides more HSP in cells.
  • Thanks to our generous donors, AFIP has been able to conduct an L-glutamine study.
  • L-glutamine intake has a significant effect on HSP levels in the blood and provides more energy.
  • AFIP is setting up a new study to test whether L-glutamine reduces episodes of atrial fibrillation.

L-glutamine heeft gunstig effect op HSP en energie in het lichaam

AFIP researchers found a significant change in the HSP levels in the blood of almost all patients as a result of L-Glutamine intake. Moreover, they have also observed the impact of L-Glutamine on the energy balance of the body.

During atrial fibrillation, several energy makers are affected. L-Glutamine intake ensures normalization of energy makers such as:

  • Carbohydrates: needed for energy
  • Nucleotides: necessary for the production of DNA
  • Amino acids: necessary for building proteins
  • Vitamins: needed for growth and development

These findings suggest that L-glutamine intake may have a beneficial effect on energy status in AF patients, potentially reducing atrial fibrillation episodes. This will soon be tested by AFIP in the Glutaminimize AF study.

Will you become a donor? Thanks to donations from patients and organizations such as Hart4Onderzoek and Stichting Coolsingel, we have established the first L-Glutamine study.

Glutaminimize AF study

Due to all the aforementioned positive effects of L-glutamine on HSP and energy values ​​in the body, the AFIP Foundation is going to set a follow-up study in motion.

In the Glutaminimize study, the AFIP Foundation will investigate whether L-glutamine can help reduce episodes of atrial fibrillation.

These patients are firstly given a wristband that can measure atrial fibrillation. Subsequently, we map out how often patients have an episode with atrial fibrillation. After that, the patient can begin taking the L-glutamine for 6 months. During these 6 months we can continuously monitor the heart rhythm and determine whether L-glutamine causes fewer episodes of atrial fibrillation.

Donate to the L-Glutamine study

Donate today to take the L-Glutamine to the next stage with us.

Thanks to your donations


L-glutamine studie

L-Glutamine herstelt energie levels en biedt potentie om te beschermen tegen boezemfibrilleren.


GGA studie

Dit middel helpt bij het herstellen van celschade en helpt beschermen tegen boezemfibrilleren in experimentele modellen.

Man in Lab


Genetisch AF poli

Meerdere patiënten geven aan dat boezemfibrilleren in de familie zit. Wij hebben geluisterd en zetten een genetisch AF poli op in Rotterdam.

Agnes Muskens verpleegkundige stichting AFIP


Agnes Muskens

Door jullie donaties is AFIP een communicatie superster rijker. Agnes Muskens support iedereen op ons platform.

Also co-created
with the AFIP community

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