Prof. dr. Natasja MS de Groot works as a cardiologist-electrophysiologist (electrophysiologist is a medical specialist in the treatment of cardiac arrhythmias) at the Erasmus Medical Center in Rotterdam. She studied medicine at the University of Leiden after which she undertook PhD research into the mechanism of atrial arrhythmias at both the Leiden University Medical Center and the Cardiovascular Research Institute Maastricht. She completed her training as a cardiologist at the Leiden University Medical Center. Since 2009 she has been working at the Erasmus Medical Center where she leads the translational electrophysiology research group. She is also the principal investigator of the Academic Center of Excellence for Atrium Fibrillation.

She is co-author of several international guidelines on the diagnosis and treatment of cardiac arrhythmias. In her clinical activities she specializes in the treatment of atrial arrhythmias in patients with congenital heart defects, cardiac arrhythmias in children, and genetically determined cardiac arrhythmias. In 2014 she was appointed Associate Professor and in 2015 she became a board member of the European Heart Rhythm Association, where she is responsible for communication with healthcare professionals and patients within the European member states.