DnAFix project: Unraveling of genetic causes of atrial fibrillation, from mechanism to treatment

Younger people may experience atrial fibrillation due to a genetic cause. The German-Dutch research team has identified atrial fibrillation families that carry mutations in genes responsible for proteins of the cytoskeleton, the building blocks of heart cells.   Recently published findings from the lab of Prof. Bianca Brundel indicate that atrial fibrillation causes DNA damage [...]

(ENGELS) Atrial fibrillation causes DNA damage and energy depletion in the heart

Atrial Fibrillation (AF) is the most common clinical tachyarrhythmia with a strong tendency to progress in time. AF progression is driven by derailment of protein homeostasis, which ultimately causes electrical conduction changes and contractile dysfunction of the atria. New research published in Nature Communications by the group of Prof. Bianca Brundel (VUmc) in collaboration with [...]